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Synthesis of some racemicγ-fluoro-α-amino acids

✍ Scribed by S. Kröger; G. Haufe


Book ID
105168851
Publisher
Springer
Year
1997
Tongue
English
Weight
688 KB
Volume
12
Category
Article
ISSN
0939-4451

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Stereoselective Synthesis of Some γ- and
✍ Kröger, Stefan ;Haufe, Günter 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 705 KB

## Abstract (__R__)‐(−)‐2‐Amino‐4‐fluorobutyric acid (4c) (32% ee) and six of its homologues 9 have been synthesized by diastereoselective alkylation (54–72% yield) of (__R__)‐(+)‐camphor‐based glycine ester imines 1 with 1‐bromo‐2‐fluoro‐alkanes 6, at low temperature, followed by deprotection. Sim