Stereoselective Synthesis of Some γ- and
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Kröger, Stefan ;Haufe, Günter
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Article
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1997
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John Wiley and Sons
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English
⚖ 705 KB
## Abstract (__R__)‐(−)‐2‐Amino‐4‐fluorobutyric acid (4c) (32% ee) and six of its homologues 9 have been synthesized by diastereoselective alkylation (54–72% yield) of (__R__)‐(+)‐camphor‐based glycine ester imines 1 with 1‐bromo‐2‐fluoro‐alkanes 6, at low temperature, followed by deprotection. Sim