✍ Scribed by Gregory M. Shutske; Joachim E. Roehr
No coin nor oath required. For personal study only.
A number of 3‐substituted 6‐piperazinylpyrazolo[3,4‐b]pyridines were synthesized from 2,6‐difluoropyridine by directed ortho metallation and sequential intra‐ and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3‐position showed activity as selective serotonin re‐uptake inhibitors.
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## Abstract Two 2,3‐dihydro‐2‐(4‐pyridinyl)‐1__H__‐isoindoles 2a,b have been synthesized by the reaction of isoindoline with 4‐chloropyridines. In addition, a number of 1‐alkyl‐2,3‐dihydro‐2‐(4‐pyridinyl)‐1__H__‐isoindoles 2c‐h were obtained from 2‐(4‐pyridinyl)phthalimide (5). The addition of alky
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