Synthesis of some new substituted ethanone hydrazones containing 1H-1,2,4-triazole and thiazole
β Scribed by Fang-Ming Liu; Ya-Dong Sun; Zheng-Feng Xie
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 62 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Abstract
Three new thiosemicarbazones have been synthesized by condensation reaction of 2βbromoβ1βarylethanones with thiosemicarbazide, which reacted with various 2βbromoβ1βarylethanones in ethanol under refluxing to give a series of substituted ethanone hydrazone derivatives. Their structures were confirmed by elemental analysis, IR, ^1^H NMR, and MS spectra.
π SIMILAR VOLUMES
## Abstract The synthesis of 1,2,4βtriazole and thiazole analogs of ketoconazole is described in which one of the Ξ± azole ring carbons is linked to Cβ2 of the ketal by means of a three methylene tether. Lithiation of 1βmethylβ1,2,4βtriazole and thiazole and subsequent alkylation with 2β(2,4βdichlor