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Synthesis of Some New Substituted Ethanone Hydrazones Containing 1H-1,2,4-Triazole and Thiazole.

✍ Scribed by Ya-Dong Sun; Fang-Ming Liu; Zheng-Feng Xie


Publisher
John Wiley and Sons
Year
2005
Weight
18 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract The synthesis of 1,2,4‐triazole and thiazole analogs of ketoconazole is described in which one of the Ξ± azole ring carbons is linked to C‐2 of the ketal by means of a three methylene tether. Lithiation of 1‐methyl‐1,2,4‐triazole and thiazole and subsequent alkylation with 2‐(2,4‐dichlor