✦ LIBER ✦

Synthesis of Some New 2-(Phenoxyacetylthio)-3-aryl-6-bromo- or -6,8-dibromoquinazoline-4(3H)-ones a Possible AChE Inhibitors

✍ Scribed by Km. Kanchan Hajela; Anil K. Sengupta; Kripa Shanker; Dinesh C. Doval

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 192 KB
Volume: 316
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19833160509

No coin nor oath required. For personal study only.

✦ Synopsis

Sixteen new 2-(phenoxyacetylthio)-3-aryl-6-bromo-or -6,8-dibromoquinazolones were synthesized by condensation of various phenoxyacetyl chlorides with mercaptoquinazolones. Their inhibitory properties towards choline esterase and their bactericidal activities were studied in vitro. Nine of the compounds exhibited (> 50 %) choline esterase inhibition, whereas the antibacterial screening showed moderate results.

Synthese einiger neuer Z(Phenoxyacetyltbio)-3-aryl.6-brola-oder 6,&dibromchioazolia4(3H)oae ds potentieue Acetylcholinesteraee-Hemmer Die Synthese von 16 neuen 2-(Phenoxyacetylthio)-3-aryl-6-brom-oder 6,8-dibrom-chinazolonen durch Kondensation verschiedener Phenoxyacetykhloride mit Mercaptochinazolonen wird beschrieben. Ihre cholinesterasehemmende Wirkung und antibakterielle Aktivitat wurden in vitro gepriift . 9 Verbindungen zeigten starke Cholinesterasehemmung, aber nur maSige antibakterielle

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