A convenient synthesis of 5-amino-6-aryl-3-(β-D-galacto- or -β-D-glucopyranosyl)tetrahydro-2-thioxo-4H-1,3-thiazin-4-ones

✍ Scribed by Yadav, Lal Dhar S. ;Yadav, Danveer S.

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 288 KB
• Volume: 1995
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.1995199512310

✦ Synopsis

Abstract

The Michael addition of the sulfur nucleophiles N‐(β‐D‐galacto‐ or ‐β‐D‐glucopyranosyl)dithiocarbamic acid (2a, b) to 4‐arylidene‐5‐oxazolones (3a‐d) followed by ring transformation of the resultant Michael adducts 4a‐h and hydrolysis yielded new 5‐amino‐6‐aryl‐3‐(β‐D‐galacto‐ or ‐β‐D‐glucopy‐ranosyl)‐tetrahydro‐2‐thioxo‐4__H__‐1,3‐thiazin‐4‐ones 6a‐h in a one‐pot procedure.