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Synthesis of Some 3H labeled 2′, 3′-dideoxynucleosides of pharmacological interest

✍ Scribed by George F. Taylor; John A. Kepler

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
312 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

Pyr imi d i ne-5-3H12 ' ,3 ' -dideoxycyt idine and [ribose 2 , 3--3H]2' , 3 ' - dideoxyinosine are prepared by catalytic reduction with tritium gas.

[Adenine-8-3H]2'3'-dideoxyadenosine i s prepared by catalytic exchange witn tritium gas. by the action of adenosine deaminase on [adenine-8-3H]2',3'-dideoxy- adenosine.

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