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Synthesis of some 1-(dihydroxypropyl)pyrazolo[3,4-d]-pyrimidines and in vivo evaluation of their antileishmanial and antitrypanosomal activity

✍ Scribed by F Gatta; F Perotti; L Gradoni; M Gramiccia; S Orsini; G Palazzo; V Rossi


Book ID
103629359
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
594 KB
Volume
25
Category
Article
ISSN
0223-5234

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✍ Soad M. Abdel-Gawad; M. M. Ghorab; A. M. Sh. El-Sharief; F. A. El-Telbany; M. Ab πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 111 KB

## Abstract 2‐Benzyl‐ and 2‐aryloxymethyl‐3‐amino‐1‐phenyl‐pyrazolo[3,4‐__d__]pyrimidine‐4‐ones **__5a–f__** have been synthesized by reacting the corresponding arylacetylamino derivatives **__3a–f__** with hydrazine hydrate. Thionation of compounds **__5d–f__** by action of P~2~S~5~ in pyridine yi