Soluble polymer-supported synthesis of B
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Min Xia; Yan-Guang Wang
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Article
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2002
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Elsevier Science
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French
β 94 KB
An efficient and general liquid-phase synthesis of Biginelli compounds has been developed. Polyethylene glycol (PEG) bound acetoacetate reacted with urea and aldehydes under reflux or solvent-free microwave irradiation conditions to afford PEG-supported 3,4-dihydropyrimidin-2(1H)-ones. The desired 3