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Synthesis of short oligoribonucleotides bearing a 3'- or 5'-terminal phosphate by use of 4,4',4"-tris(4,5-dichlorophthalimido)trityl as a new 5'-hydroxyl protecting group

โœ Scribed by Sekine, Mitsuo.; Hata, Tsujiaki.


Book ID
126793363
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
851 KB
Volume
108
Category
Article
ISSN
0002-7863

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โœ Kohji Seio; Mitsuo Sekine ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

A phosphoramidite unit having 4-monomethoxytritylthio as a new 5%-hydroxyl protecting group was prepared and employed in oligonucleotide synthesis. The new phosphoramidite enabled the synthesis of oligonucleotides without the use of acids such as TFA or DCA.