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Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5′-hydroxyl protecting group: toward oligonucleotide synthesis without acid treatment

✍ Scribed by Kohji Seio; Mitsuo Sekine

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 82 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01873-1

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✦ Synopsis

A phosphoramidite unit having 4-monomethoxytritylthio as a new 5%-hydroxyl protecting group was prepared and employed in oligonucleotide synthesis. The new phosphoramidite enabled the synthesis of oligonucleotides without the use of acids such as TFA or DCA.

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