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Synthesis of (S-(−)-wybutine, the fluorescent minor base from yeast phenylalanine transfer ribonucleic acids

✍ Scribed by Taisuke Itaya; Akemi Mizutani


Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
289 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis


The Wittig reaction of l-benzyl-7-formylwye

amino] ethyl] triphenylphosphonium chloride (8) followed by successive methylation and reduction gave (-) -wybutine


📜 SIMILAR VOLUMES


Synthesis of [R-(R∗,S∗)]- and [S-(R∗,R∗)
✍ Taisuke Itaya; Tae Kanai; Takehiko Iida 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 213 KB

The synthesis of the title compounds started with the Vilsmeier reaction of 3-[2,3,5-tris-O-(tert-butylalmethylsilyl)-~-D-ribofuranosyl]wye (b'b) and proceeded through the Wittig reaction with (R)-N-(methoxyearbonyl)-3-(triphenylphosphonio)alaninate (4), methylation with trimethyisilyldiazomethane,