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Synthesis of optically active forms of hydroxy-y base, the minor component of rat liver phenylalanine transfer ribonucleic acid

โœ Scribed by Taisuke Itaya; Nobuhide Watanabe; Akemi Mizutani


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
250 KB
Volume
27
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


R-(i?*,S*) I-E-Hydroxywybutine (8) and its [S-(R*,R*)]-isomer (9) have been synthesized

as the most probable alternatives for hydroxy-Y base isolated from rat liver phenylalanine tRNA.


๐Ÿ“œ SIMILAR VOLUMES


Synthesis of [R-(Rโˆ—,Sโˆ—)]- and [S-(Rโˆ—,Rโˆ—)
โœ Taisuke Itaya; Tae Kanai; Takehiko Iida ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 213 KB

The synthesis of the title compounds started with the Vilsmeier reaction of 3-[2,3,5-tris-O-(tert-butylalmethylsilyl)-~-D-ribofuranosyl]wye (b'b) and proceeded through the Wittig reaction with (R)-N-(methoxyearbonyl)-3-(triphenylphosphonio)alaninate (4), methylation with trimethyisilyldiazomethane,