Synthesis of (S)- and (R)-3-hydroxyhexadecanoic acid
✍ Scribed by Barbara Jakob; Gundula Voss; Hans Gerlach
- Book ID
- 108038461
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 481 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Summahy: E-(RI -5-tfydkoxy-Z-hexenoic acid (4) and the acetovúde 06 E-(4R, 5R, 7R) -tihydtoxy-2--ootenoic acid (31 am joined tu &e, a&tm depkotecLLon, (+J-coUeeeRo&oL (ll. The. nqnthue,s 06 thc two hq&oxq-ati& @am poey-(RI -3-hydhoxy-bt&anoa& (P/+BJ uñd (-)-Ramtah¿c acid, ~enpec.a%wLq, am otimd.
## Abstract The synthesis of (__R__)‐ and (__S__)‐2‐hydroxy‐3‐enoic acid esters [(__R__)‐1a‐d and (__S__)‐1a‐c] is described. The (__R__) enantiomers were prepared by a Pinner synthesis from the corresponding (__R__)‐cyanohydrins [(__R__)‐2a‐d], which in turn were obtained by R‐oxynitrilase‐ (E.C.
Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi