𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases

✍ Scribed by Dalhoff, Christian; Lukinavičius, Gražvydas; Klimašauskas, Saulius; Weinhold, Elmar

Book ID
109945881
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
291 KB
Volume
1
Category
Article
ISSN
1750-2799

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Efficient Synthesis of S-Adenosyl-L-Homo
Efficient Synthesis of S-Adenosyl-L-Homocysteine Natural Product Analogues and Their Use to Elucidate the Structural Determinant for Cofactor Binding of the DNA Methyltransferase M·HhaI
✍ Marc Pignot; Goran Pljevaljcic; Elmar Weinhold 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 312 KB 👁 2 views

5Ј-Acetylthio-5Ј-deoxy-2Ј,3Ј-O-isopropylideneadenosine (8) was directly prepared from commercially available 2Ј,3Ј-Oisopropylideneadenosine ( 7) and thioacetic acid under Mitsunobu conditions in almost quantitative yield. In situ cleavage of the acetylthio function of 8 followed by coupling with dif

Mammalian alkaloids: Synthesis and O-met
Mammalian alkaloids: Synthesis and O-methylation of (S)- and (R)-3′-hydroxycoclaurine and their N-methylated analogues with S-adenosyl-L-[methyl-14C]methionine in presence of mammalian catechol O-methyltransferase
✍ Xiao-Shu He; Dragana Tadić; Malgorzata Brzostowska; Arnold Brossi; Maureen Bell; 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 German ⚖ 805 KB

## Abstract __O__‐Methylation of the optically active 3′‐hydroxycoclaurines 3a and 3b and of the __N__‐methylated analogs 5a,b with __S__‐adenosyl‐L‐[__methyl__‐^14^C]methionine in presence of mammalian COMT was investigated __in vitro.__ The __N__‐unsubstituted (1__S__)‐ and (1__R__ )‐isomers 3a a