ChemInform Abstract: Efficient Synthesis of S-Adenosyl-L-Homocysteine Natural Product Analogues and Their Use to Elucidate the Structural Determinant for Cofactor Binding of the DNA Methyltransferase M×HhaI.

Efficient Synthesis of S-Adenosyl-L-Homo

Efficient Synthesis of S-Adenosyl-L-Homocysteine Natural Product Analogues and Their Use to Elucidate the Structural Determinant for Cofactor Binding of the DNA Methyltransferase M·HhaI

✍ Marc Pignot; Goran Pljevaljcic; Elmar Weinhold 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 312 KB 👁 1 views

5Ј-Acetylthio-5Ј-deoxy-2Ј,3Ј-O-isopropylideneadenosine (8) was directly prepared from commercially available 2Ј,3Ј-Oisopropylideneadenosine ( 7) and thioacetic acid under Mitsunobu conditions in almost quantitative yield. In situ cleavage of the acetylthio function of 8 followed by coupling with dif