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Synthesis of (S)-3,4-Diaminobutanenitriles as Precursors for 3-Amino-GABA Derivatives

✍ Scribed by Peter Gmeiner; Evi Hummel; Christian Haubmann; Georg Höfner

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
368 KB
Volume
328
Category
Article
ISSN
0365-6233

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4-Amino-3-(aminomethyl)benzoic acid (1) (AmAbz) is a novel unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics and as a scaffold for combinatorial chemistry. It was efficiently synthesized in three steps (63% overall yield) from 4-aminobenzoic a