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Synthesis of rotenoid derivatives with cytotoxic and topoisomerase II inhibitory activities

✍ Scribed by Supranee Sangthong; Kuakarun Krusong; Nattaya Ngamrojanavanich; Tirayut Vilaivan; Songchan Puthong; Supajittra Chandchawan; Nongnuj Muangsin


Book ID
113495877
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
510 KB
Volume
21
Category
Article
ISSN
0960-894X

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In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy-and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compou