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Synthesis of riccardin B by nickel-catalyzed intramolecular cyclization

✍ Scribed by Masahiko Iyoda; Masahiro Sakaitani; Hiroki Otsuka; Masaji Oda

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 248 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94949-9

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✦ Synopsis

Riccardin B, a macrocyclic bis(bibenzy1) possessing cytotoxic activity, and its dehydroxy derivative were synthesized in high yields using the nickel-catalyzed intramolecular coupling of the acyclic precursors.

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