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Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

✍ Scribed by Kasumi Sanpei; Yoshio Saito; Masaya Imoto; Kazuo Umezawa; Kuniki Kato

Book ID: 103983583
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 195 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00459-3

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✦ Synopsis

The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-o~-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.

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