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Isolation and Structure Determination of Novel Phosphatidylinositol Kinase Inhibitors, Echiguanines A and B, from Streptomyces sp.

โœ Scribed by Nishioka, Hiroshi; Sawa, Tsutomu; Nakamura, Hikaru; Iinuma, Hironobu; Ikeda, Daishiro; Sawa, Ryuichi; Naganawa, Hiroshi; Hayashi, Chigusa; Hamada, Masa; Takeuchi, Tomio; Iitaka, Yoichi; Umezawa, Kazuo


Book ID
126212265
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
302 KB
Volume
54
Category
Article
ISSN
0163-3864

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Synthesis of ribofuranosyl glycosides of
โœ Kasumi Sanpei; Yoshio Saito; Masaya Imoto; Kazuo Umezawa; Kuniki Kato ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 195 KB

The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-o~-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.