Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid

✍ Scribed by Merritt B. Andrus; Jing Liu; Erik L. Meredith; Edward Nartey

• Book ID: 104253816
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 222 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01131-6

✦ Synopsis

The phytoalexin resveratrol has been made using a decarbonylative Heck reaction. The acid chloride derived from 3,5-dihydroxybenzoic acid was coupled with 4-acetoxystyrene in the presence of palladium acetate and N, N-bis-(2,6-diisopropylphenyl)dihydroimidazolium chloride to give the substituted stilbene in 73% yield as the key step.