Synthesis of Racemic, Optically Active and Radioactive α-Lipoic Acids
✍ Scribed by Acker, D. S.; Wayne, W. J.
- Book ID
- 121195558
- Publisher
- American Chemical Society
- Year
- 1957
- Tongue
- English
- Weight
- 729 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
## Abstract The reaction of O‐menthyl phenylphosphonite **__1__** with aromatic aldehydes in the presence of Me~3~SiCl provided the O‐menthyl α‐hydroxyphosphinates **__2__**. Acidic hydrolysis of **__2__** gave the corresponding α‐hydroxyphosphinic acids **__3__**. The (+)‐enantiomer of **__3a__**
Simple amino acids (1) can be converted in fair to good yield into hydrazino acids (3) of like configuration by using KOCI instead of NaOCl to promote the Shestakov rearrangement of the intermediate hydantoic acids (2). It was shown fifteen years ago by Karady et al.,' and later by Custafsson,' that