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Synthesis of racemic cis-1-alkyl- and 1-aryl-2-aminocyclopropanecarboxylic esters

✍ Scribed by Sven Mangelinckx; Norbert De Kimpe

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
246 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The title cyclic b-amino esters were synthesized stereo-and regioselectively. Starting from the corresponding 1-aryl-and 1-alkylcyclopropane-1,2-dicarboxylates, selective monosaponification and subsequent Curtius reaction leads to certain cis-1-alkyland 1-aryl-2-aminocyclopropanecarboxylic esters. These b-aminocyclopropanecarboxylate derivatives (b-ACCs) can be seen as useful building blocks for b-peptides.

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