## Abstract Starting from the known lactol (I) and using its stereogenic center at C‐4, title compound (VI), a brine‐shrimp toxic and antifungal marine metabolite, is obtained in a 5‐step procedure.
Synthesis of (R)-(+)-Tanikolide, a Toxic and Antifungal δ-Lactone from the Marine Cyanobacterium Lyngbya majuscula
✍ Scribed by Matsuo, Keizo; Hikita, Junko; Nishiwaki, Keiji
- Book ID
- 118276587
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 659 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0385-5414
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The first total synthesis of lyngbyabellin A, a novel peptolide from the marine cyanobacterium Lyngbya majuscula, is described. Both functionalized thiazole carboxylic acid units were synthesized using our CMD (chemical manganese dioxide) oxidation from the corresponding thiazolidines. The asymmetri