Synthesis of (R)- and (S)-5-(Hydroxymeth
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Erwin G. J. C. Warmerdam; Johannes Brussee; Arne van der Gen; Chris G. Kruse
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Article
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1994
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John Wiley and Sons
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German
β 332 KB
## Abstract The (__R__)β and (__S__)β5β(hydroxymethyl)β3βisopropyloxazolidinβ2βones, ((__R__)β and (__S__)β2, resp.), pivotal intermediates in the preparation of optically active Ξ²βblockers, were synthesized using (__R,E__)β2βhydroxypentβ3βenenitrile (1) as the chiral starting material. In the synt