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Synthesis of (R)- and (S)-5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one, intermediates in the preparation of optically active β-blockers

✍ Scribed by Erwin G. J. C. Warmerdam; Johannes Brussee; Arne van der Gen; Chris G. Kruse

Publisher
John Wiley and Sons
Year
1994
Tongue
German
Weight
332 KB
Volume
77
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The (R)‐ and (S)‐5‐(hydroxymethyl)‐3‐isopropyloxazolidin‐2‐ones, ((R)‐ and (S)‐2, resp.), pivotal intermediates in the preparation of optically active β‐blockers, were synthesized using (R,E)‐2‐hydroxypent‐3‐enenitrile (1) as the chiral starting material. In the synthesis of (R)‐2, a known cyclization/inversion step was applied.

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