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Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists

✍ Scribed by Yoshihiro Ida; Toru Nemoto; Shigeto Hirayama; Hideaki Fujii; Yumiko Osa; Masayuki Imai; Takashi Nakamura; Toshiyuki Kanemasa; Akira Kato; Hiroshi Nagase


Book ID
113495614
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
729 KB
Volume
20
Category
Article
ISSN
0968-0896

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We synthesized pyrrolomorphinan derivatives 6, 7, and 9 to examine whether the pyrrole ring would be an accessory site in the j opioid receptor selective antagonist, nor-binaltorphimine. Derivative 6 had an a,b-unsaturated ketone substituent that strongly bound to the j receptor. The compound with t