𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene method

✍ Scribed by Hidetsura Cho; Shinsuke Matsuki; Akira Mizuno; Hirokazu Annoura; Toshio Tatsuoka

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
375 KB
Volume
34
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A highly convenient method for the synthesis of 2‐substituted pyrrole derivatives 7a‐c from pyrrole using phosgene was developed. Successively, 7‐methyl‐6,7‐dihydro‐1__H__,5__H__‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1a and 6,7‐dihydro‐1__H__,5__H__‐pyrrolo[2,3‐c]azepine‐4,8‐dione 1b (aldisin) were synthesized by phosphorus pentoxide/methanesulfonate and polyphosphoric acid cyclization.

📜 SIMILAR VOLUMES

Synthesis of 2,3,5-substituted pyrrole d
Synthesis of 2,3,5-substituted pyrrole derivatives
✍ Paula M.T. Ferreira; Hernâni L.S. Maia; Luı́s S. Monteiro 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 147 KB

Substituted pyrrole derivatives are prepared by treatment of 2,3-dihydrofuran derivatives with trifluoroacetic acid. These in turn are obtained by Michael addition of carbon nucleophiles of the b-dicarbonyl type to N-(4-toluenesulfonyl)-N-(tertbutyloxycarbonyl)-dehydroalanine methyl ester.

Optimization of the Suzuki coupling reac
Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives
✍ Marija Alešković; Nikola Basarić; Kata Mlinarić-Majerski 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 233 KB

## Abstract A facile three‐step synthesis of 2‐(2‐aminophenyl)pyrrole (**1**) and 2‐[(2‐aminomethyl)phenyl]pyrrole (**2**) is reported by use of Suzuki coupling of __N__‐Boc‐pyrrol‐2‐yl boronic acid (**3**) and o‐substituted aryl halogenides, followed by hydrogenation. The Pd‐catalyzed cross‐coupli