Synthesis of Pyrrolo- and Pyrido-[1,2-a]benzimidazolequinone Antitumor Agents Containing a Fused Cyclopropane Ring.
โ Scribed by John O'Shaughnessy; Fawaz Aldabbagh
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 28 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
## Abstract The key step in the synthesis of new five, six and sevenโmembered alicyclic ring [1,2โ__a__]โfused bioreductive benzimidazolequinones was radical cyclisation. Six and sevenโmembered tributyltin hydrideโmediated homolytic aromatic substitutions of nucleophilic __N__โalkyl radicals onto t
## Abstract The synthesis of the title compounds was achieved using the key intermediate ethyl 4,6โdimethylโ3โ(pyrrolโ1โyl)thieno[2,3โ__b__]pyridineโ2โ carboxylate 2. This latter compound was obtained __via__ the interaction of the thienopyridine amino ester 1 with 2,5 dimethoxytetrahydrofuran in a