Synthesis of Pyrrolidine Based Natural or Unnatural Product Derivatives. Part 1. Application of Efficient Asymmetric Induction of C-2 Position in Polysubstituted Pyrrolidines.

Synthesis of pyrrolidine based natural o

Synthesis of pyrrolidine based natural or unnatural product derivatives (1): Application of efficient asymmetric induction of C-2 position in polysubstituted pyrrolidines

✍ Hyung Jae Jeong; Ju Man Lee; Min Kyu Kim; Sang-Gyeong Lee 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 60 KB

## Abstract A novel method for synthesis of polysubstituted pyrrolidines, which possess a C‐2 stereocenter, was developed. The strategy involves Grignard addition to the succinimide, derived from L‐tartaric acid, followed by stereocontrolled triethylsilane promoted reduction of the resulting cyclic