Synthesis of pyrrolidine based natural or unnatural product derivatives (1): Application of efficient asymmetric induction of C-2 position in polysubstituted pyrrolidines

✍ Scribed by Hyung Jae Jeong; Ju Man Lee; Min Kyu Kim; Sang-Gyeong Lee

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2002
• Tongue: English
• Weight: 60 KB
• Volume: 39
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570390525

✦ Synopsis

Abstract

A novel method for synthesis of polysubstituted pyrrolidines, which possess a C‐2 stereocenter, was developed. The strategy involves Grignard addition to the succinimide, derived from L‐tartaric acid, followed by stereocontrolled triethylsilane promoted reduction of the resulting cyclic amidols.