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Synthesis of pyrimidinones by action of benzamidine on a benzocycloheptenic β-keto ester

✍ Scribed by Nadine Muller; Robert Granet; Lucette Lepage; Pierre Krausz; Jean-Paul Laval

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
104 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The synthesis of a polycyclic heterocyclic ring system compound, ethyl 7‐hydroxy‐4‐oxo‐2‐phenyl‐4,5‐dihydro‐3__H__‐benzo[6,7]cyclohepta[1,2‐d]pyrimidine‐6‐carboxylate was carried out by condensation of benzamidine on diethyl 5,9‐dihydroxy‐7__H__‐benzo[a]cycloheptene‐6,8‐dicarboxylate, after opening and then closure of the seven membered ring.

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