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Synthesis of pyrimidine analogues of the nucleoside antibiotic ascamycin

✍ Scribed by Castro-Pichel, Julia ;García-López, M. Teresa ;De las Heras, Federico G. ;Herranz, Rosario

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
564 KB
Volume
1988
Category
Article
ISSN
0947-3440

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A facile synthesis of ascamycin and rela
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## Abstract A concise route to nucleoside β‐hydroxyphosphonate analogues is described. The use of a nucleoside β‐ketophosphonate as the key intermediate allowed both the (__R__) and (__S__) isomers of β‐hydroxyphosphonate analogues in the pyrimidine series to be accessed. Such derivatives may be co