Synthesis of pyrido[3,2-e]pyrrolo[2,1-c][1,2,4]triazines from pyrido[3,2-e][1,2,4]triazine derivatives

✍ Scribed by Francesco Savelli; Alessandro Boido; Giovanni Ciarallo

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1999
• Tongue: English
• Weight: 374 KB
• Volume: 36
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570360405

✦ Synopsis

Abstract

In carrying on our interest in heteropolycyclic structures with biological activities, we projected the preparation of compounds containing the pyrido[3,2‐e][1,2,4]triazine or pyrido[2,3‐b][1,4]triazepine systems. The established synthetic approach for the preparation of latter system led to the triazine derivatives 5a‐f while a new bicyclic triazepine structure 6 is accomplished with difficulty.

In expanding the pyridotriazine structure, we obtained derivatives of a new tricyclic structure, 5‐substituted‐6a‐ethyloxycarbonyl‐5,6,6a,7‐tetrahydropyrido[2,3‐e]pyrrolo[2,1‐c][1,2,4]triazin‐9(8__H__)‐ones 8 in which the triazine ring is fused with a pyrrole nucleus.

Compounds 5a‐f and 8a,b will be tested as potential CNS depressant, antiinflammatory, analgesic and antibacterial agents.