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Synthesis of pyrido [4,3-f]-1,5-thiazepine as a potential antihypertensive agent

✍ Scribed by Won-Hun Ham; Chang-Young Oh; Tae-Gyun Lim; Yun-Ho Jung; Young-Hoon Jung


Book ID
112961087
Publisher
Springer
Year
1995
Tongue
English
Weight
190 KB
Volume
18
Category
Article
ISSN
0253-6269

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5(4H)-ones / 2-Chloro-N-cyanomethyl-N-methylnicotinamide / Aromatic nucleophilic substitution A new synthesis of pyrido[3,2-f][1,4]thiazepine derivatives 3 starting with 2-chloronicotinic acid (1), methylaminoacetonitrile hydrochloride and carbon disulfide is described. As proved by a crystal struct