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Synthesis of pyridazine derivatives through the unexpected intermediate 5-amino- 4-cyano -2,3-dihydro-furan-2,3-disulfonic acid disodium salt

✍ Scribed by Barbara Cacciari; Giampiero Spalluto; Valeria Ferretti

Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
79 KB
Volume
40
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

An unexpected compound (5‐amino‐4‐cyano‐2,3‐dihydrofuran‐2,3‐disulfonic acid disodium salt, 4) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile. Its structure was undoubtly identified through crystal structure analysis. Compound 4 was highly stable and it was isolated easily and in a very high yield. Its reactivity was studied in the reactions with some hydrazine derivatives in order to obtain different pyridazine analogs.

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Phenacyl esters of acetic acid derivativ
Phenacyl esters of acetic acid derivatives and their application for the synthesis of 2-oxo-4-phenyl-5-(phenylhydrazono)-2,5-dihydro-furan-3-derivatives
✍ Jan Hlaváč; Pavel Hradil; Radek Mělnický; Lubomír Kvapil; Petr Šlézar; Martin Gr 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 437 KB

## Abstract magnified image Coupling of various substituted phenacyl acetates **1** and diazonium salts **3** was studied. If the phenacyl acetates were substituted by an electronaceptor group such as CN or COOEt 3‐substituted phenyl‐5‐(phenyl‐hydrazono)‐5__H__‐furan‐2‐ones **4** were formed. Also