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Synthesis of pyrazolopyridine 3-carboxylates by Friedlander condensation

✍ Scribed by Raghunath B. Toche; Dinesh C. Bhavsar; Muddassar A. Kazi; Sandeep M. Bagul; Madhukar N. Jachak

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
112 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of 1,3,6‐trisubstituted and 1,3,5,6‐tetrasubstituted pyrazolo [3,4‐b] pyridines 5 have been synthesized by series of reactions on 1‐phenyl‐3‐carboxylate pyrazolone to obtain o‐aminoaldehyde, which undergo facile condensation with various α‐methylene ketones, nitriles, and esters, furnish fused pyridine derivative in good yield. J. Heterocyclic Chem., (2010).

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