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Synthesis of benzo[3,4-h][1,6]naphthyridines via Friedländer condensation with active methylenes

✍ Scribed by Ramhari V. Rote; Sandeep M. Bagul; Deepak P. Shelar; Sandeep R. Patil; Raghunath B. Toche; Madhukar N. Jachak

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
146 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Novel 4‐amino‐6‐chloroquinoline‐3‐carbaldehyde has been synthesized by synchronous reduction by lithium aluminiumhydride and finally oxidation with MnO~2~. Friedländer condensation of it with reactive methylenes furnished novel benzo[3,4‐h][1,6]naphthyridine derivatives. J. Heterocyclic Chem., (2011).

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