Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation
✍ Scribed by Ahmed H. Shamroukh; Magdi E. A. Zaki; Eman M. H. Morsy; Faiza M. Abdel-Motti; Farouk M. E. Abdel-Megeid
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 786 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0365-6233
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## Abstract Pyrazolo‐[3,4‐__d__]pyrimidine‐4,6‐diones **5** and pyrazolo[4,3‐__d__]pyrimidine‐5,7‐diones **7** were synthesized by Curtius rearrangement of pyrazolic mono‐esters **2** and **3** followed by hetero‐cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.
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Synthesis of New 2-Substituted-pyrazolo[4',3':5,6]pyrano[3,2e][1,2,4]triazolo [1,5-c]pyrimidine Derivatives. -Starting from pyrazole (III) the pyrimidine (V) is prepared which is further treated with different carboxylic acid derivatives to form novel pyrimidines of type (VI) and (VIII). Preparatio