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Synthesis of pyrazolo[3,4-b]pyridines using ammonium acetate as green reagent in multi-component reactions

✍ Scribed by Madhukar N. Jachak; Appasaheb B. Avhale; Bhausaheb K. Ghotekar; Dhananjay B. Kendre; B. Toche Raghunath


Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
228 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

magnified image

Several new pyrazolo[3,4‐b]pyridine derivatives were synthesized by one pot cyclocondensation of the components; 5‐amino‐3‐aryl‐1__H__‐phenylpyrazoles, p‐substituted benzoylacetonitriles and some aldehydes. The condensations were most effective by using ammonium acetate as the base catalyst; triethylamine was also studied as a catalyst.


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