Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells
β Scribed by Liu, Ying-Rui; Luo, Ji-Zhuang; Duan, Pan-Pan; Shao, Jing; Zhao, Bao-Xiang; Miao, Jun-Ying
- Book ID
- 121274067
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 891 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-894X
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## Abstract Title compounds (III) are obtained by a microwaveβassisted oneβstep procedure.
A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, (1)H NMR, HRMS, and X-ray ana
## Abstract Aberrant arachidonic acid (AA) metabolism has been involved in inflammation and carcinogenesis. The key enzymes in AA metabolism such as cytosolic phospholipase A2 (cPLA~2~) and cyclooxygenaseβ2 (COXβ2) have been implicated in the development and progression of many human cancers, inclu