✦ LIBER ✦

Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells

✍ Scribed by Liang-Wen Zheng; Ying Li; Di Ge; Bao-Xiang Zhao; Ying-Rui Liu; Hong-Shui Lv; Jun Ding; Jun-Ying Miao

Book ID: 104004589
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 897 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.121

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✦ Synopsis

A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, (1)H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.

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