Synthesis of Protected l-4-[Sulfono(difluoromethyl)]phenylalanine and Its Incorporation into a Peptide
β Scribed by Liu, Shifeng; Dockendorff, Chris; Taylor, Scott D.
- Book ID
- 111902374
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 53 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1523-7060
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A r&able prqxwation of S%yanm~y~4-th ad its incorporation into oligoribnucleoddes is reported. Deproteciion qf oligo&otuuleotidks with DBU in acetonitrile followed by methanolic amraonio allmvs the use of standard N-benwyl and N-isoburyrylp7otectedp~~~r~t~. Cleavage of hammerhead rikqvmes using GCG
## Abstract [1Sβ(1R\*,2S\*,3R\*)]β3β[[1β(Cyclohexylmethyl)β2,3βdihydroxyβ5βmethylhexyl]βamino]βNβ[Nβ(4βmorpholinosulfonyl)βLβ phenylalanyl]β3βoxoβDLβalanine methyl ester (PD 132002) was found to be a renin inhibitor and thus potentially useful for the treatment of hypertension. This peptidomimetic