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ENANTIOSELECTIVE SYNTHESIS OF N-Boc AND N-Fmoc PROTECTED DIETHYL 4-PHOSPHONO(DIFLUOROMETHYL)-L-PHENYLALANINE (F 2 Pmp)

✍ Scribed by Smyth, Mark S.; Burke, Terrence R.


Book ID
120464215
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
284 KB
Volume
28
Category
Article
ISSN
0030-4948

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A facile solution and solid phase synthe
✍ Maher N. Qabar; Jan Urban; Michael Kahn πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 407 KB

The F2Pmp derivatives were prepared in 80-90% yield from commercially available protected L-4-iodophenylalanine by esterification with diazomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover, treatment of L-4-iodoPhe-containing peptides under