𝔖 Bobbio Scriptorium
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Synthesis of potentially prebiotic RNA precursors: Adenine and uracil derivatives

✍ Scribed by John B.J. Pavey; John D. Sutherland; George W. Weaver; J.Nicole Whitfield

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
179 KB
Volume
36
Category
Article
ISSN
0040-4039

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The d-allo-and l-talo-hept-6-ynofuranosyluracil-derived phosphoramidites 11A and 11T were prepared in 9 Β± 10% yield over eight steps from the previously described propargylic alcohols 1A and 1T, respectively. The corresponding nucleotides were incorporated into rU 14 by standard solid-phase synthesi