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Synthesis of Potentially Antineoplastic Derivatives of N-[N-(2-Chloroethyl)-N-nitrosocarbamoyl]amino Acids

✍ Scribed by Wei-Ci Tang; Gerhard Eisenbrand

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
351 KB
Volume
314
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

The synthesis of N‐[N‐(2‐chloroethyl)‐N‐nitrosocarbamoyl]amino acids and their anilides, congeners of N‐(2‐chloroethyl)‐N‐nitrosoureas, as potential antineoplastic substances is reported. N‐[N‐(2‐chloroethyl)‐N‐nitrosocarbamoyl]amino acids are prepared by reaction of amino acids with N‐(2‐chloroethyl)‐N‐nitrosocarbamoyl azide. Corresponding anilides and toluidides are obtained by condensation of the primary reaction products with aniline and toluidine using dicyclohexylcarbodiimide (DCC).

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