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Synthesis of Potential Thrombin Inhibitors. Incorporation of Tartaric Acid Templates as P2 Proline Mimetics

✍ Scribed by Anders Dahlgren; Jonas Brånalt; Ingemar Kvarnström; Ingemar Nilsson; Djordje Musil; Bertil Samuelsson


Book ID
108479169
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
340 KB
Volume
10
Category
Article
ISSN
0968-0896

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Synthesis of functionally diverse bicycl
✍ Stephen Hanessian; Helen Sailes; Eric Therrien 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 266 KB

Bicyclic sulfonamides were synthesized from 4-alkenyl N-alkenylsulfonyl L-prolines using a ring-closure metathesis reaction. Three types of bicyclic sulfonamides varying in the size of the second ring (5,5; 5,6; 5,7) were synthesized. A sulfonamide counterpart of an indolizidinone 2-carboxylic acid