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ChemInform Abstract: Synthesis of Potential Thrombin Inhibitors. Incorporation of Tartaric Acid Templates as P2 Proline Mimetics.

โœ Scribed by Anders Dahlgren; Jonas Branalt; Ingemar Kvarnstroem; Ingemar Nilsson; Djordje Musil; Bertil Samuelsson


Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
33
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of Substi
โœ Peter Nuhn; A. Herrmann; M. Radman ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 1 views

Synthesis of Substituted Benzoyl Acrylic Acids as Potential Inhibitors of Phospholipase A 2 . -Acylation of long-chain alkylbenzenes with maleic anhydride derivatives under Friedel-Crafts conditions provides access to benzoylacrylic acids [cf. (III)/(IV), (VIII)], which are evaluated for their abili