𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of potential 99mTc nitrido tumor imaging disposition in mice

✍ Scribed by M. Borel; M. Rappi; R. Pasqualini; J.C. Madelmont; D. Godeneche; A. Veyre

Publisher
Elsevier Science
Year
1992
Weight
881 KB
Volume
43
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

✦ Synopsis

Several cationic or neutral technetium-nitrido complexes of Schiff bases [for which 5-methyl 3-(2-hydroxyphenyl methylene) dithiocarbazate (L1) was a prototype], bis-aminoethanethiol (BAT-TM) and macrocyclic amines were prepared. We report here, the synthesis and isolation of these TcNLn complexes from reaction mixtures by high pressure liquid chromatography or sephadex G25 column. In vivo tissue distribution studies were performed on tumor bearing mice (B16, EMT6, 3LL) after i.v. injection of 10-20 microCi of TcNLn. Although pharmacokinetic differences appeared between the three studied ranges, we did not obtain proof of any particular specificity to tumor tissues. Nevertheless, the complexes were very stable and some of the ligands could be used as chelators after linking side chains or groups inducing specific tumor localization.

📜 SIMILAR VOLUMES

Synthesis and biodistribution in mice of
Synthesis and biodistribution in mice of a new 99mTc nitrido complex for brain imaging
✍ Junbo Zhang; Xuebin Wang; Jing Liu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 117 KB

## Abstract The bis(__N__‐cyclopentyl dithiocarbamato) nitrido technetium‐99m complex ^99m^TcN(CPEDTC)~2~ was synthesized by the reduction of ^99m^TcO into [^99m^Tc≡N]^2+^ with stannous chloride in the presence of succinic dihydrazide and propylenediamine tetraacetic acid, followed by the addition

Synthesis and biodistribution of novel 9
Synthesis and biodistribution of novel 99mTc-nitrido methylpiperidine dithioformate derivatives as potential brain imaging agents
✍ Jie Lu; Mingyan Xu; Hongmei Jia; Shuxia Xi; Yimeng Wang; Xuebin Wang 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 258 KB

## Abstract Three dithioformate ligands with methyl substituted on the piperidine rings, potassium 1‐(2‐methylpiperidine‐1‐yl)‐dithioformate (2‐mp), potassium 1‐(3‐methylpiperidine‐1‐yl)‐dithioformate (3‐mp) and potassium 1‐(4‐methylpiperidine‐1‐yl)‐dithioformate (4‐mp) were synthesized. The corres